Sleep and Mammalian Hibernation: Homologous Adaptations and Homologous Processes?
نویسندگان
چکیده
منابع مشابه
Homologous recombination in mammalian cells.
Mouse LTKcells were transfected with a pair of defective Herpes simplex virus thymidine kinase ( t k ) genes. One tk gene had an 8-bp insertion mutation while the second gene had a 100-bp inversion. Extrachromosomal homologous recombination leading to the reconstruction of a functional tk gene was monitored by selecting for tk positive cells using medium supplemented with hypoxanthine/ aminopte...
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An understanding of the protein adaptations that support mammalian hibernation is coming from several different approaches. New studies in my lab are (a) using cDNA library screening to identify genes that are up-regulated in hibernation, (b) analyzing the role of reversible protein phosphorylation in the control of membrane ion pumps in torpor, (c) assessing temperature-dependent properties of...
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There are hypotheses in the history of human culture and civilization in which we can find undeniable similarities and commonalities among them, despite their vastly different cultural and historical contexts. For example, finding commonalities between the language of two artistic aesthetic hypotheses, Sufism and Surrealism, which are very different from each other in terms of context, time as ...
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Gene targeting in mammalian cells has proven invaluable in biotechnology, in studies of gene structure and function, and in understanding chromosome dynamics. It also offers a potential tool for gene-therapeutic applications. Two limitations constrain the current technology: the low rate of homologous recombination in mammalian cells and the high rate of random (nontargeted) integration of the ...
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Both negative (1-5) and positive (6-9) evidence may be found in the literature for the occurrence of tumor-specific cytotoxic antibody in heterologous antisera to mammalian tumor cells. The negative evidence appears to have been due to the intervention of species-specific antibody. In a further examination of this question, we have studied the cytotoxicity and absorption reactions of rabbit ant...
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ژورنال
عنوان ژورنال: Sleep
سال: 1993
ISSN: 1550-9109,0161-8105
DOI: 10.1093/sleep/16.4.372